19.04.24
Use of multimodality and molecular imaging to understand mechanisms of atherosclerotic plaque biology and identify high-risk inflammatory phenotypes in cardiovascular disease, to improve risk-stratification and inform the clinical translation of novel therapeutic strategies.
Junior Research Fellow
Wellcome Clinical Research Career Development Fellow & Honorary Consultant Cardiologist
Jason Tarkin is a Junior Research Fellow at St Catharine’s College. He is a Wellcome Clinical Research Career Development Fellow and Honorary Consultant Cardiologist at the University of Cambridge. He is also an elected member of the British Society of Cardiovascular Imaging committee.
After graduating summa cum laude with honours in Biology from the University of New Hampshire in 2003, Jason studied Medicine at St George’s, University of London where he received distinction in Clinical Sciences in 2008. His medical training was in the London Deanery.
In 2017, he was awarded a PhD from the University of Cambridge, where he studied at Gonville & Caius College. For his Wellcome Trust-funded doctoral research on somatostatin receptor PET imaging of atherosclerotic inflammation, Jason won both the Melvin Judkin’s Young Investigator Award from the American Heart Association in 2016, and the William W Parmley Young Author Achievement Award from the American College of Cardiology in 2018, among other prestigious awards.
Jason trained in Cardiology at the Bart’s Heart Centre, Addenbrooke’s Hospital, and Hammersmith Hospital, where he was also an NIHR Academic Clinical Lecturer at the National Heart & Lung Institute. His clinical subspecialty is cardiovascular imaging.
Wall C, Huang Y, Le EPV, Ćorović A, Uy CP, Gopalan D, Ma C, Manavaki R, Fryer TD, Aloj L, Graves MJ, Tombetti E, Ariff B, Bambrough P, Hoole SP, Rusk RA, Jayne DR, Dweck MR, Newby D, Fayad ZA, Bennett MR, Peters JE, Slomka P, Dey D, Mason JC, Rudd JHF, Tarkin JM. Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis. Eur Heart J Open 2021 [Online ahead of print]
Tarkin JM, Wall C, Gopalan D, Luigi Aloj, Martin R Bennett, Eric O Aboagye, James E Peters, Rudd JHF, Mason JC. A novel approach to imaging active Takayasu arteritis using somatostatin receptor PET/MRI ligands. Circ Cardiovasc Imaging 2020; 13(6):e010389.
Tarkin JM, Calcagno C, Dweck MR, Evans NR, Chowdhury MM, Gopalan D, Newby DE, Fayad ZA, Bennett MR, Rudd JHF. 68Ga-DOTATATE PET identifies residual myocardial inflammation and bone marrow activation after myocardial infarction. J Am Coll Cardiol 2019; 73(19):2489-2491.
Tarkin JM, Joshi FR, Evans NR, Chowdhury MM, Figg NL, Shah AV, Starks LT, Manavaki R, Martin-Garrido A, Yu E, Kuc RE, Grassi L, Kreuzhuber R, Kostadima M, Frontini M, Ouewhand WH, Groves AM, Gopalan D, Kirkpatrick PJ, Coughlin PA, Buscombe JR, Fryer TD, Bennett MR, Warburton EA, Davenport AP, Rudd JH. Detection of atherosclerotic inflammation by 68Ga-DOTATATE PET compared to 18F-FDG PET imaging J Am Coll Cardiol 2017;69(14):1774-91.
Tarkin JM, Ćorović A, Wall C, Rudd JHF. Positron emission tomography imaging in cardiovascular disease. Heart 2020; 106(22):1712-1718.
Tarkin JM, Dweck MR, Rudd JHF. Imaging as a surrogate marker of drug efficacy in cardiovascular disease. Heart 2019; 105(7):567-578.
Tarkin JM, Dweck MR, Evans NR, Takx RA, Brown AJ, Tawakol A, Fayad ZA, Rudd JH. Imaging Atherosclerosis. Circ Res 2016;118(4):750-69.
Tarkin JM, Joshi F, Rudd JHF. PET Imaging of Inflammation in Atherosclerosis. Nat Rev Cardiol 2014;11(8):443-57.
ACC William W Parmley Young Author Achievement Award, 2018; BCS Young Investigator Award (runner-up), 2017; AHA Melvin Judkin’s Young Investigator Award, 2016; Royal Society of Medicine Cardiology Presidents Medal (2nd prize), 2015
2021
