Professor Sir Mark Welland

• Protein mis-folding problems related to human diseases such as Alzheimer’s • Drug design formulations based on nanotherapeutics for glioblastoma, tuberculosis and Type II diabetes • Interactions of proteins with surfaces • Nanoelectronics for future generation communications and sensing

Professor Sir Mark Welland started his career in nanoscience and nanotechnology at IBM Research Laboratories (Yorktown Heights, USA), where he was part of the team that developed one of the first scanning tunnelling microscopes. In 1985, appointed to a Lectureship in Electrical Engineering at the University of Cambridge, he set up the first tunnelling microscopy group in the UK, and in 1991 he began the Nanoscience Research Group.

Sir Mark established a purpose-built facility at the University of Cambridge, the Nanoscience Centre, which undertakes a variety of nano-related research programmes of an interdisciplinary nature.  This was the base for the Interdisciplinary Research Collaboration (IRC) in Nanotechnology of which Sir Mark was the Director, and whose highly successful legacy has been far reaching. He established the Science and Technology Research Centre at the American University in Cairo, Egypt, that he co-directed from 2003 to 2010, and from 2008 to 2012 was for the UK, the International Principal Investigator of the $100M World Premier Research Institute in nanomaterials based in Tsukuba, Japan. 

From April 2008 until May 2012, Sir Mark was Chief Scientific Adviser to the UK Government Ministry of Defence. He is currently Master of St Catharine’s College, and Head of Electrical Engineering and Director of the Nanoscience Centre at the University of Cambridge.

Barnes, J. R., Stephenson, R. J., Welland, M. E., Gerber, C., & Gimzewski, J. K. (1994). Photothermal spectroscopy with femtojoule sensitivity using a micromechanical device. Nature, 372(6501), 79-81.

Krecmer, P., Moulin, A. M., Stephenson, R. J., Rayment, T., Welland, M. E., & Elliott, S. R. (1997). Reversible nanocontraction and dilatation in a solid induced by polarized light. Science, 277(5333), 1799-1802.

Cowburn, R. P., & Welland, M. E. (2000). Room temperature magnetic quantum cellular automata. Science, 287(5457), 1466-1468.

Alexandra E. Porter, Mhairi Gass, Karin Muller, Jeremy N. Skepper, Paul A. Midgley & Mark Welland (2007). Direct imaging of single-walled carbon nanotubes in cells. Nature Nanotechnology 2, 713–717 (2007)

Knowles, T. P., Fitzpatrick, A. W., Meehan, S., Mott, H. R., Vendruscolo, M., Dobson, C. M., . . . Welland, M. E. (2007). Role of intermolecular forces in defining material properties of protein nanofibrils.. Science, 318(5858), 1900-1903.

Knowles, T. P., Waudby, C. A., Devlin, G. L., Cohen, S. I., Aguzzi, A., Vendruscolo, Welland M. E. and Dobson, C. M. (2009). An analytical solution to the kinetics of breakable filament assembly.. Science, 326(5959), 1533-1537.

Tuomas P. J. Knowles, Tomas W. Oppenheim, Alexander K. Buell, Dimitri Y. Chirgadze & Mark E. Welland. Nanostructured films from hierarchical self-assembly of amyloidogenic proteins. Nature Nanotechnology 5, 204–207 (2010)

Myriam M. Ouberai, Ana L. Gomes Dos Santos, Sonja Kinna, Shimona Madalli, David C. Hornigold, David Baker, Jacqueline Naylor, Laura Sheldrake, Dominic J. Corkill, John Hood, Paolo Vicini, Shahid Uddin, Steven Bishop, Paul G. Varley & Mark E. Welland. Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly. Nature Communications 8, Article number: 1026 (2017)