After completing his PhD in Biological Science at Corpus Christi, Dr Harris joined the MRC Laboratory of Molecular Biology at the University of Cambridge as a Postdoctoral Fellow, specialising in cryo-EM reconstruction of bacterial protein filaments involved in cell division and plasmid DNA segregation. During this time, he was a Teaching Associate at St Catharine's, supervising the College's medical and veterinary undergraduates.
Since 2018, Dr Harris has been a Research Associate in the University's Department of Biochemistry, where he is applying his cryo-EM expertise to the reconstruction and computational modelling of antibiotic transport by bacterial tripartite efflux pumps and related membrane proteins.
Webber A., Ratnaweera M., Harris A., Luisi B.F., Ntsogo Enguéné V.F. A model for allosteric communication in drug transport by the AcrAB-TolC tripartite efflux pump. Antibiotics (2022), 11(1), 52.
Harris A., Wagner M., Du D., Raschka S., Nentwig L.-M., Gohlke H., Smits H.J.S., Luisi B.F., Schmitt L. Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nature Communications (2021), 12(1), 5254. Preprint: bioRxiv; doi: https://doi.org/10.1101/2021.02.09.430491
Du D., Neuberger A., Orr M.W., Newman C.E., Hsu P.-C., Samsudin F.F., Szewczak-Harris A., Ramos L.M., Debela M., Khalid S., Storz G., Luisi B.F. Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environment. Structure (2020), 28(6), 625–634. Preprint: bioRxiv; doi: https://doi.org/10.1101/813394
Szewczak-Harris A., Wagstaff J., Löwe, J. Cryo‐EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 Å resolution. FEBS Letters (2019), 593(15), 1915–1926. Preprint: bioRxiv 638619; doi: https://doi.org/10.1101/638619
Szewczak-Harris A., Löwe, J. Cryo-EM reconstruction of AlfA from Bacillus subtilis reveals the structure of a simplified actin-like filament at 3.4-Å resolution. PNAS (2018), 115(13), 3458-3463. Preprint: bioRxiv 190744; doi: https://doi.org/10.1101/190744
Fink G., Szewczak-Harris A., Löwe, J. The Bacterial Cytoskeleton—filament systems in archaea and bacteria. Cell (2016), 166(1), 552.
Jarzyniak K., Banasiak J., Szewczak A., Jasiński M. A novel Medicago truncatula ABC transporter from the G subfamily. Biotechnologia (2013), 94(1), 77.