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Dr Andrzej Harris

Fellow
Subject: Natural Sciences
Tutor, Postgraduate Tutor
Research Associate

After completing his PhD in Biological Science at Corpus Christi, Dr Harris joined the MRC Laboratory of Molecular Biology at the University of Cambridge as a Postdoctoral Fellow, specialising in cryo-EM reconstruction of bacterial protein filaments involved in cell division and plasmid DNA segregation. During this time, he was a Teaching Associate at St Catharine's, supervising the College's medical and veterinary undergraduates.

Since 2018, Dr Harris has been a Research Associate in the University's Department of Biochemistry, where he is applying his cryo-EM expertise to the reconstruction and computational modelling of antibiotic transport by bacterial tripartite efflux pumps and related membrane proteins. 

Webber A., Ratnaweera M., Harris A., Luisi B.F., Ntsogo Enguéné V.F. A model for allosteric communication in drug transport by the AcrAB-TolC tripartite efflux pump. Antibiotics (2022), 11(1), 52. 

Harris A., Wagner M., Du D., Raschka S., Nentwig L.-M., Gohlke H., Smits H.J.S., Luisi B.F., Schmitt L. Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nature Communications (2021), 12(1), 5254. Preprint: bioRxiv; doi: https://doi.org/10.1101/2021.02.09.430491

Du D., Neuberger A., Orr M.W., Newman C.E., Hsu P.-C., Samsudin F.F., Szewczak-Harris A., Ramos L.M., Debela M., Khalid S., Storz G., Luisi B.F. Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environment. Structure (2020), 28(6), 625–634. Preprint: bioRxiv; doi: https://doi.org/10.1101/813394

Szewczak-Harris A., Wagstaff J., Löwe, J. Cryo‐EM structure of the MinCD copolymeric filament from Pseudomonas aeruginosa at 3.1 Å resolution. FEBS Letters (2019), 593(15), 1915–1926. Preprint: bioRxiv 638619; doi: https://doi.org/10.1101/638619

Szewczak-Harris A., Löwe, J. Cryo-EM reconstruction of AlfA from Bacillus subtilis reveals the structure of a simplified actin-like filament at 3.4-Å resolution. PNAS (2018), 115(13), 3458-3463. Preprint: bioRxiv 190744; doi: https://doi.org/10.1101/190744

Fink G., Szewczak-Harris A., Löwe, J. The Bacterial Cytoskeleton—filament systems in archaea and bacteria. Cell (2016), 166(1), 552. 

Jarzyniak K., Banasiak J., Szewczak A., Jasiński M. A novel Medicago truncatula ABC transporter from the G subfamily. Biotechnologia (2013), 94(1), 77.

2020