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Professor Anthony Davenport

Fellow

Subject:

1995
Role of apelin and 'orphan' G-protein coupled receptor systems in the human vasculature and their role in cardiovascular disease, novel agents for imaging atherosclerosis. Function of G-protein coupled receptors in the human cardiovascular system in health and disease.
Professor of Cardiovascular Pharmacology

Anthony Davenport is Professor of Cardiovascular Pharmacology, University of Cambridge, and was previously British Heart Foundation Principal Scientist and for ten years held a BHF Science Lectureship.  He is a Fellow and active member of the British Pharmacological Society and was previously chair of External Affairs, Trustee, Finance and Executive member.  He is also a Fellow of the Hypertension Society and International Fellow of the American Heart Association.  He is an executive member of the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, that maintains a data base of drugs and their target at http://www.guidetopharmacology.org/, chair of the Endothelin Receptor Sub-committee, member of the International Scientific Advisory Board on Endothelin; editorial board member of Current Opinions in Pharmacology; editor of 'Receptor binding Techniques'. He has held programme grants from the BHF and was co-applicant on three MRC programme grants to establish the multi-imaging facilities at Addenbrooke's Hospital.  He was elected British Pharmacological Society Australasian Visitor in 2014. In 2018, he was named as a Highly Cited Researcher as determined by a citation analysis of Web of Science data. 

  • Read, C., Nyimanu, D.,  Williams, T.L.,  Huggins, D.J.,   Sulentic, P.,   Macrae, R.G.C.,  Yang, P., Glen, R.C., Maguire, J.J. and Davenport, A.P. (2019) International Union of Basic and Clinical Pharmacology CVII. Structure and pharmacology of the apelin receptor with a recommendation that Elabela/Toddler is a second endogenous peptide ligand. 71, 467-502.

  • Yang, P., Read, C., , Kuc, R.E., Buonincontri, G., Southwood, M., Torella, R., Upton, P.D., Crosby., A., Sawiak. S.J., Carpenter, T.A., Glen, R.C., Morrell, N.W., Maguire, J.J. and Davenport, A.P. (2017). Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation, 135, 1160–1173.

  • Davenport, A.P., Hyndman, K.A.,  Dhaun, N.,   Southan, C.,  Kohan, D.E.,  Pollock, J.S., Pollock, D.M.,  Webb, D.J. and  Maguire, J.J., (2016) Endothelin.  Pharmacol  Rev, 68, 366-427.
  • Irkle, A.,  Vesey, A.T., Lewis; D.Y., Skepper, J.N., Bird; J.L.E., Dweck; M.R.,  Joshi; F.R.,  Gallagher; F.A.,  Warburton; E.A.,  Bennett; M.R., Brindle; K.M., Newby, D.E., Rudd, J.H., Davenport, A.P. (2015) Identifying active vascular micro-calcification by 18F-sodium fluoride positron emission tomography. Nature Communications, 6, 1-11. (26151378).
  • Brame,  A.L., Maguire, J.J.,  Yang,  BA, Dyson, A, Torella, R., Cheriyan, J., Singer, M., . Glen, R.C.,  Wilkinson, I.B.,  Davenport, A.P. (2015). Design, characterization and first-in-human study of the vascular actions of a novel ‘biased’ apelin receptor agonist.  Hypertension, 65, 834-840.
  • Maguire, J.J., K.L. Jones, R.E. Kuc, M.C. Clarke, M.R. Bennett, and A.P. Davenport. (2014). The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro. Cardiovasc Res 101: 513-21.
  • Maguire JJ, Davenport AP.(2014) Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. Brit J Pharmacol. doi: 10.1111/bph.12874
  • Azizan, E.A., H. Poulsen, P. Tuluc, J. Zhou, M.V. Clausen, A. Lieb, C. Maniero, S. Garg, E.G. Bochukova, W. Zhao, L.H. Shaikh, C.A. Brighton, A.E. Teo, A.P. Davenport, T. Dekkers, B. Tops, B. Kusters, J. Ceral, G.S. Yeo, S.G. Neogi, I. McFarlane, N. Rosenfeld, F. Marass, J. Hadfield, W. Margas, K. Chaggar, M. Solar, J. Deinum, A.C. Dolphin, I.S. Farooqi, J. Striessnig, P. Nissen, and M.J. Brown. (2013). Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nature Genetics 45: 1055-60.
  • Davenport, A.P., Alexander, S.H.P., Sharman, J.L., Pawson, A.J., Benson, H.E., Monaghan, A.E., Chiy Liew, W., . Mpamhanga, C.P., Bonner, T.I., Neubig, R.R., Pin, J P. , Spedding, M. and Harmar, A. J. (2013). International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands. Pharmacological Review, 65, 967-986.
  • Maguire,J.J., Kleinz,M.J., Pitkin,S.L., Davenport,A.P.(2009) [Pyr1]apelin-13 identified as the predominant apelin isoform in human heart: vasoactive mechanisms and inotropic action in disease. Hypertension, 54:598-604).