Professor Stefan Marciniak

Fellow
2011
Proteins destined for secretion or for insertion into the cell membrane are first folded within the endoplasmic reticulum. The process of protein folding can become defective in many disease states such as hypoxia, malignancy and some forms of diabetes. When the level of misfolded proteins within the endoplasmic reticulum increases, the cell is said to experience “endoplasmic reticulum stress”. I wish to understand the cellular consequences of endoplasmic reticulum stress; in particular its effects on tissue growth and cell survival. In doing so, we hope to identify targets for the development of novel therapies.
Director of studies in medicine (1A); Supervisor (homeostasis MVST 1A)
Professor of Respiratory Science; MB/PhD programme director

Stefan Marciniak is Professor of Respiratory Science at the University of Cambridge and Honorary Consultant Respiratory Physician at Addenbrooke’s and Papworth Hospitals.  He is Director of the University of Cambridge MB/PhD Programme. He was himself a member of the Cambridge MB/PhD Programme before undertaking post-doctoral research at New York University funded by the Wellcome Trust and in Cambridge as an MRC Clinician Scientist.  He set up his his in the Cambridge Institute for Medical Research and an MRC Senior Clinical Research Fellow.  His clinical interests focus on pleural medicine, particularly the genetics of pneumothorax and the biology of mesothelioma. 

  • Chambers J.E., Kubankova M., Huber, R., López-Duart I, Avezov E., Bond P., Marciniak S.J.*, Kuimova, M.* (2018) An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. ACS Nano  12:4398-4407. *Joint senior authors
  • Malzer E., Dominicus C.S., Chambers J.E., Dickens J.A., Mookerjee S., Marciniak S.J. (2018).  The integrated stress response regulates BMP signalling through effects on translation.  BMC Biology 16:34 https://doi.org/10.1186/s12915-018-0503-x
  • Scott R.M., Henske E.P., Raby B., Boone P.M., Rusk R.A., Marciniak S.J. (2018).  Familial pneumothorax – towards precision medicine. Thorax 73:270-276.
  • Dickens J.A., Ordóñez A., Chambers J.E., Beckett A.J., Patel V., Malzer E., Dominicus C.S., Bradley J., Peden A.A., Prior I.A., Lomas D.A., Marciniak S.J. (2016).  The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.  FASEB J 30: 4083-4097.
  • Chambers J.E., Dalton L.E., Subramanian D.N., Gooptu B., Balan A., Park S-P., Holden S., Marciniak S.J. (2015). Spontaneous pneumothorax can be associated with TGFBR2 mutation. Eur. Respir. J. 46: 1832-1835.
  • van ‘t Wout E.F.A., van Schadewijk A., van Boxtel R., Dalton L.E., Clarke H.J., Tommassen J., Marciniak S.J.*, Hiemstra P.S.* (2015).  Virulence factors of Pseudomonas aeruginosa induce both the unfolded protein and integrated stress responses in airway epithelial cells.  PLoS Pathogens 11(6): e1004946. doi:10.1371/journal.ppat.1004946 *Joint senior authors
  • Chambers, J.E., Dalton, L.E., Clarke, H.J., Malzer, E., Dominicus, C.S., Patel, V., Moorhead, G.B.G., Ron, D., and Marciniak, S.J. (2015). Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. eLIFE doi.org/10.7554/eLife.04872.
  • Chen, R., Rato, C., Yan, Y., Crespillo-Casado, A., Clarke, H.J., Harding, H.P., Marciniak, S.J.*, Read, R.J.*, and Ron, D.* (2015). G-actin provides substrate-specificity to eukaryotic initiation factor 2a holophosphatase. eLIFE doi.org/10.7554/eLife.04871. *Joint senior authors
  • Nikolic M.Z., Lok L.S.C., Mattishent K., Barth S., Yung B., Cummings N., Wade D., Vali Y., Chong K., Wilkinson A., Mikolasch T., Brij S., Jenkins H.S., Kamath A., Pasteur M., Hopkins T., Wason J., Marciniak S.J. (2015) Non-interventional statistical comparison of BTS and ACCP guidelines for size and severity in primary pneumothorax. Eur. Respir. J. 45: 1731-4.